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Technology

Mouse hybridoma lines were generated against the CPG2-specific peptide to obtain 3 monoclonal antibodies to CPG2. The antibodies are specific to the clathrin-coated pits in the postsynaptic zone in glutamatergic synapses. This unique specificity enables high-resolution imaging of glutamatergic synapses, in contrast to antibodies to other proteins such as PSD-95 that are expressed in other synaptic sites. Glutamatergic synapses are the most common type of synapse in the brain, and are a major area of research in both biology and neuroscience labs. These antibodies enable imaging and measurement of protein levels related to neuronal activity in rodent models, providing new tools for a large community of researchers.