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CPG2 is a protein that is regulated by neuronal activity in the rodent brain. CPG2 is uniquely expressed in the postsynaptic zones of glutamatergic synapses, so antibodies to CPG2 would be an excellent tool for studying excitatory synaptic activity in mice and rats. This technology is a set of 3 monoclonal antibodies to CPG2 that can be used for Western blotting, immunohistochemistry, and immunoprecipitation. No other antibodies to rodent CPG2 currently exist, so this technology enables new experimental approaches in neuroscience and biology research. An application for this monoclonal antibody is to study excitatory neuronal activity.