Header and Body 2

Problem Addressed

DNA nanostructures, also known as DNA origami, are 3D structures made of numerous short staple strands of DNA which guide the folding of a long scaffold polynucleotide strand into a custom polyhedral shape. There are currently several computational design tools that facilitate manual, bottom-up programming of DNA origami to form a desired shape using complementary Watson-Crick base pairing. However, only one approach tackles the inverse problem of using the geometry of a target shape to design a DNA nanostructure, and this method has its limitations. For example, it is only semi-automated and may produce unstable nanostructures that are unsuitable for many applications. Additionally, the geometries produced through this method must be spherical, restricting its scope. This MIT technology is fully automated and can produce a wide variety of non-spherical shapes, providing more versatility for applications with specific shape requirements.