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Problem Addressed

The production of neurons from non-neural cells is an integral aspect of the modeling and development of therapies for neurodegenerative diseases. Current methods of generating neurons from non‑neuronal cells are inefficient and have an efficacy rate of less than 20%. This technology employed a novel assay to identify genes needed for highly efficient neurogenesis in C. elegans and provides suggested uses of these genes and their mammalian analogs for study and treatment of diseases in the human nervous system.