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Sangeeta Bhatia and colleagues have developed a method that addresses this problem, with a modular delivery system that allows for predictive targeting of siRNA to tissues of interest in a highly specific manner. Their approach involves the non-covalent attachment of a homing peptide, which binds to a specific cell surface receptor, and protein transduction domain, which facilitates cellular entry, to the siRNA. Unlike many other previously described tissue-specific delivery approaches, components in this method can be rationally designed in a predictive manner, and therefore be easily adapted to many cell types. Furthermore, the components are non-cytotoxic and do not provoke an immune response from the host.