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Problem Addressed

Existing methods of producing flavonoids through fermentation require supplementation of the culture media with phenylpropanoic precursors -- expensive compounds that add significantly to production cost. Additionally, these methods also require two different culture media formulations to support protein expression and flavonoid production respectively. This two-stage culture introduces process complexity that complicates efforts to scale up flavonoid production. This invention addresses this problem with novel strains of microbes that enable flavonoid production in a single medium formulation without precursor supplementation.