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Problem Addressed

Salmochelins are highly conserved small metal ion chelators, also known as siderophores, synthesized by pathogenic gram-negative bacteria (E. coli, Salmonella enterica, and certain Klebsiella strains) in the stomach and small intestines. Salmochelins are vital to the survival of these pathogenic strains, and because they cannot be bound and destroyed by the host organism's natural response system, they enhance bacterial virulence. The ability to introduce immunogenic carrier proteins to salmochelin-producing strains of bacteria would provide general immunization against all of these pathogenic strains simultaneously.