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Problem Addressed

Existing methods for producing conjugates of nanoparticles and biological molecules (e.g., carbodiimide crosslinker chemistry) are largely inefficient, non-specific, and require multiple steps. This single-step synthetic route uses engineered E. coli to produce molecular linkages that self-assemble to reliably form micron-scale chains of nanoparticle-biomolecule conjugates. The bonds are formed within minutes and are highly specific and stable.