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This invention provides real-time internal monitoring of vital signs with improved accuracy over external measurements, useful for field assessment of patients or home monitoring and management of chronic illnesses. This device may also be used for operational safety monitoring for military personnel or first responders, or to improve performance and safety for athletes. This device can detect a number of medical conditions including, sepsis, arrhythmias, aortic stenosis, hypertrophy, asthma and chronic obstructive pulmonary disease (COPD) exacerbations.