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Technology

With this novel DNA repair capability assessment kit, cells are transfected with a library of plasmid DNA reporters containing various types or doses of DNA damage. The repair of DNA damage results in a measurable change in fluorescent reporter protein expression. Therefore, each fluorescent reporter color corresponds to the repair of a different type or dose of DNA damage. Fluorescence is measured by flow cytometry or laser scanning cytometry. A 96 well plate of cell samples can be assessed at once, allowing for high throughput and straightforward multiplexing.