The capability to recognize and isolate small bioparticles present at low concentrations in a fluid has significant utility in the diagnosis and management of diseases such as HIV and cancer. However, existing N/MEMS platforms are unable to access many nanometer-scale particles of clinical interest. Furthermore, previous attempts at nanoscale filtering are impaired by low flow rates as a result of low permeability. This invention overcomes these limitations by advancing on-chip bioparticle manipulation into previously unexplored length scales (e.g. HIV virus, ~100 nm) while retaining Darcy drag 4-5 orders of magnitude lower than existing porous materials.