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This technology describes a novel class of 3D molecular-layered nanoporous materials (High Definition Nanomaterials, or HDnanomaterials) that can be used to construct fluidic devices capable of isolating and manipulating nanometer-scale particles suspended in a fluid. Such devices have applications in areas including clinical diagnostics and treatment monitoring (e.g., manipulation of HIV viral particles or circulating tumor cells), as well as the construction of high-throughput taste and smell sensors.