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Measuring analytes in the blood forms a substantial component of medical diagnostics, ranging from critical-care to point-of-care testing. This Raman-based technique facilitates the detection of slight deviations in biomarker concentrations correlated with abnormal body function. Such non-invasive continuous measurements are extremely valuable for measuring blood glucose levels in diabetic patients, as there is no need for multiple blood draws per day. Additionally, this method could allow for more effective screenings for pre-diabetes and gestational diabetes, or aid in neonatal and ICU patient monitoring.