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Technology

This technology is based on the discovery that pain-sensing nociceptor neurons specifically express high levels of ANTXR2 (also known as CMG2) a receptor for anthrax toxin. No other neuron subtypes express the ANTXR2 receptor. By using the endosomal delivery mechanisms inherent to anthrax toxin, it is possible to introduce molecular cargo into nociceptors neurons resulting in a pain-specific block without side effects. For example, molecular cargoes can be intracellularly acting toxins that inhibit or block cell-signaling pathways in vivo or inhibit or block the release of synaptic neurotransmitters eliminating pain.