Amplification of a patient's immune system is a well-established treatment strategy to combat disease. A bolstered immune system is most effectively achieved by targeting lymph nodes as they are heavily populated with leukocytes. Furthermore, slight imperfections in immunotherapeutics can induce fatal conditions including: extreme local inflammation, systemic inflammation, or septic-shock. Targeted delivery to lymph nodes allows molecules to be used more efficiently and to be administered in lower doses, which can reduce the potential for adverse reactions. This invention is amphiphilic nanoparticles (amph-NPs) which can deliver drugs directly to lymph nodes to significantly enhance vaccine and immunotherapy outcomes.